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Meeting Record |
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Author/Editor/Inventor: |
Basseres Daniela S [a]. Tizzei Edna R V [a]. Costa Fernando F [a].
Saad Sara T O [a]. |
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Institution: |
[a] Hematology and Hemotherapy Center, State University of
Campinas, Campinas, SP Brazil.
Country: Brazil.
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Title: |
Identification of a new human gene that codes for a potential
cytoskeletal protein belonging to a new sudfamily of Rho-GAP proteins. |
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Source: |
Blood. [ print] 98(11 Part 1). November 16, 200X. 11a-12a.
http://www.bloodjournal.org/ |
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Year of Publication: |
200X |
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Publication Type: |
Meeting. |
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ISSN: |
0006-4971 |
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Meeting Information: |
43rd Annual Meeting of the American Society of Hematology, Part 1,
Orlando, Florida, USA, December 07-11, 2001 |
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Languages: |
English. |
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Abstract: |
Until recently, cytoskeletal proteins were thought to provide
solely a mechanical support to the cell plasma membrane. Recent studies have
revealed, however, that cytoskeletal proteins are involved in the regulation of
major cell functions, such as cell signalling, protein trafficking, formation of
specialized membrane domains, activity modulation of ion channels, membrane
pumps and receptors, control of cell proliferation and transcription activity,
among others. Therefore, identification of new human cytoskeletal proteins is
crucial for improved understanding of cell function, since they are major
players in signal transduction pathways. Searching the ORESTES database, we
found the expressed sequence tag (EST) PM3-LT0032-231299-001-h11 that
demonstrated similarity to the pleckstrin homology (PH) domain of the
cytoskeletal protein beta-spectrin... |
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Major Concepts: |
Molecular Genetics (Biochemistry and Molecular
Biophysics). |
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Super Taxa: |
Hominidae: Primates, Mammalia, Vertebrata, Chordata,
Animalia. |
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Organisms: |
human (Hominidae): patient. |
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Taxa Notes: |
Animals; Chordates; Humans; Mammals; Primates;
Vertebrates. |
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Parts, Structures & Systems of Organisms: |
bone marrow: blood and lymphatics, immune system; brain: nervous
system; chromosome 10; hematopoietic stem cell: blood and lymphatics; muscle:
muscular system; peripheral blood leukocyte: blood and lymphatics, immune
system; submembrane region; tonsil: blood and lymphatics, dental and oral
system, immune system. |
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Diseases: |
leukemia: blood and lymphatic disease, neoplastic
disease. |
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Chemicals & Biochemicals: |
GTPase: expression, regulation, signalling; KIAA1424; Rho-GAP
protein; actin; beta-spectrin; cDNA [complementary DNA]; cytoskeletal protein;
erythropoietin; expressed sequence tag; mRNA [messenger RNA]: expression;
pleckstrin homology domain |
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Gene Name: |
human KIAA1424 gene (Hominidae): expression. |
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Registry Numbers: |
9059-32-9: GTPASE; 132579-20-5: ACTIN; 11096-26-7:
ERYTHROPOIETIN. |
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Miscellaneous Descriptors: |
cytoskeletal organization; erythroid differentiation; Meeting
Abstract; Meeting Poster. |
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Alternate Indexing: |
Leukemia (MeSH). |
